Fmoc-D-Glu(OtBu)-OH CAS 104091-08-9

Fmoc-D-Glu(OtBu)-OH - Names and Identifiers

Name	Fmoc-D-Glu(OtBu)-OH
Synonyms	FMOC-D-GLU(TBU)-OH Fmoc-D-Glu(OBut)-OH Fmoc-D-Glu(OtBu)-OH quinoline-6-carbaldehyde FMOC-D-GLUTAMIC ACID(O-T-BUTYL) Fmoc-D-glutamic acid 5-tert-butyl ester N-Fmoc-D-glutamic acid 5-tert-butyl ester Fmoc-D-glutamic acid gamma-tert-butyl ester N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-GLUTAMIC-ACID-GAMMA-T-BUTYL ESTER N-alpha-(9-fluorenylmethyloxycarbonyl)-D-glutamic-acid-gamma-t-butyl ester N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-GLUTAMIC-ACID-GAMMA-TERT-BUTYL ESTER MONOHYDRATE (2R)-5-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name)
CAS	104091-08-9
EINECS	2017-001-1
InChI	InChI=1/C24H27NO6/c1-24(2,3)31-21(26)13-12-20(22(27)28)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/t20-/m1/s1

Fmoc-D-Glu(OtBu)-OH - Physico-chemical Properties

Molecular Formula	C24H27NO6
Molarmassa	425.47
Täthet	1.232±0.06 g/cm3(Predicted)
Melting Point	83-89°C
Boling Point	633.5±55.0 °C(Predicted)
Blixtpunkt	336.9°C
Vattenlöslighet	Slightly soluble in water.
Vapor Presure	6.39E-17mmHg at 25°C
Utseende	Solid
Färg	White to Almost white
pKa	3.70±0.10(Predicted)
Lagringstillstånd	2–8°C
Refractive Index	1.57
MDL	MFCD00077055

Fmoc-D-Glu(OtBu)-OH - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	2924 29 70

Fmoc-D-Glu(OtBu)-OH - Introduction

Fmoc-D-glutamic acid gamma-tert-butyl ester is an organic compound. Its chemical structure contains Fmoc protecting group, D-glutamic acid and gamma-tert-butyl ester group.

Nature:
Fmoc-D-glutamic acid gamma-tert-butyl ester is a white solid with a high melting point and solubility. It is relatively stable at room temperature, but will gradually hydrolyze in a humid environment.

Use:
Fmoc-D-glutamic acid gamma-tert-butyl ester is mainly used in the field of peptide synthesis as a raw material for synthetic peptides. The Fmoc protecting group can protect the amino and carboxyl groups of glutamic acid from interference during the reaction. The tert-butyl ester group can provide convenient reaction conditions and a protecting group that can be easily removed.

Preparation Method:
The preparation of Fmoc-D-glutamic acid gamma-tert-butyl ester is usually carried out by a chemical synthesis method. Specifically, D-glutamic acid is first reacted with gamma-tert-butyl ester to form the target product under appropriate conditions. Then, an Fmoc protecting group was introduced into the product, and finally Fmoc-D-glutamic acid gamma-tert-butyl ester was obtained.

Safety Information:
Fmoc-D-glutamic acid gamma-tert-butyl ester is generally safe to handle. However, as an organic compound, it may cause irritation to the skin, eyes and respiratory system. Therefore, appropriate safety measures should be taken during use, such as wearing gloves, goggles and masks, and maintaining good ventilation conditions. In addition, it is recommended to operate in a suitable laboratory environment and follow relevant safety and operating procedures. If an accident occurs, seek medical help immediately.