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Neomycin sulfate CAS1405-10-3

Chemical Name: Neomycin sulfateCAS No.: 1405-10-3Assay: ≥99.0% Appearance: White powder

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Innehåll

Neomycin sulfate Usage: Neomycin sulfate, is used as broad-spectrum antibiotic, has a good function of prevention and cure of illeness (dysentery, diarrhea, maldevelopment) dysenterywhich caused by Escherichia coli, salmonella, staphylococcus aureus, Corynebacterium diphtheriae. Neomycin sulfate Packaging and Shipping: 25KG/drum or according to clients' requirements. Neomycin sulfate Storage: in a dry and ventilated warehouse; keep away from sunshine and moisture.


NameNeomycin Sulphate
Synonymsneomix
mycigient
neobiotic
neofracin
newfrancef
neo-mantlecreme
Nystatin sulfate
neomycinesulfate
Neomycin Sulfate
Neomycin Sulphate
mycifradin sulfate
FRADIOMYCIN SULFATE
NEOMYCIN SULPHATE pure
(2S,3S,4S,5S,6S)-5-amino-2-(aminomethyl)-6-[(1S,2S,3S,4R,6R)-4,6-diamino-2-[(2R,3S,4R,5S)-4-[(2S,3S,4S,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol,sulfuric acid
CAS1405-10-3
EINECS215-773-1
InChIInChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6-,7+,8-,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23-;/m1./s1
InChIKeyOIXVKQDWLFHVGR-VTSVPHRWSA-N


Molecular FormulaC23H48N6O17S
Molarmassa712.72
Melting Point>187°C (dec.)
Boling Point1046.1°C at 760 mmHg
Specific Rotation(α)D20 +54° (c = 2 in H2O)
Blixtpunkt56℃
VattenlöslighetSoluble in water
SolubilityH2O: 50mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
Vapor Presure0mmHg at 25°C
UtseendeWhite to light yellow powder
Färgwhite to slightly yellow
Merck14,6454
PH5.0-7.5 (50g/l, H2O, 20℃)
Lagringstillstånd2–8°C
StabilityStable. Incompatible with strong oxidizing agents.
SensitiveSensitive to light and humidity
Refractive Index56 ° (C=10, H2O)
MDLMFCD00077833
UseFor broad-spectrum antibiotics, Staphylococcus aureus, diphtheria and Bacillus anthracis good
In vitro studyThe Neomycin interacts preferentially with the ribozyme-substrate complex, and this interaction leads to a reduction in the rate of cleavage, by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. Neomycin causes a conformational change in the structure of the transactivation Region (TAR), which can be detected by circular dichroism spectroscopy. Neomycin acts as a non-competitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (Koff) for the dissociation of RNA and peptides. Neomycin is the most potent of the aminoglycosides (groove binders) used to stabilize the triple helix of DNA. Neomycin stabilizes TAT, as well as the mixed-base DNA triple helix, better than the known DNA minor groove binders (which normally disrupt the triple helix) and polyamines. Neomycin stabilizes the TAT triple helix better, but can also stabilize the CGC() triple helix. Neomycin concentration-and voltage-dependent induction of partial inhibition of channels in the cytosolic and luminal surfaces. Neomycin has a greater affinity for the lumen than for the cytoplasm: the dissociation constants at zero voltage (Kb(0)) are 210.2 nM and 589.7 nM, respectively. Neomycin also showed voltage-dependent remission of inhibition at potentials greater than 60 mV.

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